Two waves of de novo methylation during mouse germ cell
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چکیده
Material Supplemental http://genesdev.cshlp.org/content/suppl/2014/07/16/28.14.1544.DC1.html References http://genesdev.cshlp.org/content/28/14/1544.full.html#ref-list-1 This article cites 36 articles, 10 of which can be accessed free at: License Commons Creative . http://creativecommons.org/licenses/by-nc/4.0/ at Creative Commons License (Attribution-NonCommercial 4.0 International), as described ). After six months, it is available under a http://genesdev.cshlp.org/site/misc/terms.xhtml six months after the full-issue publication date (see This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first
منابع مشابه
Two waves of de novo methylation during mouse germ cell development.
During development, mammalian germ cells reprogram their epigenomes via a genome-wide erasure and de novo rewriting of DNA methylation marks. We know little of how methylation patterns are specifically determined. The piRNA pathway is thought to target the bulk of retrotransposon methylation. Here we show that most retrotransposon sequences are modified by default de novo methylation. However, ...
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Mammalian germ cells undergo global reprogramming of DNA methylation during their development. Global DNA demethylation occurs around the time when the primordial germ cells colonize the embryonic gonads and this coincides with dynamic changes in chromatin composition. Global de novo DNA methylation takes place with remarkably different dynamics between the two sexes, prospermatogonia attaining...
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